The polyhedral hepatocytes (H) show a central spherical nucleus. Some of the hepatocytes are binucleated (*). The nuclei are surrounded by a granulated cytoplasm which reflects the heterogeneity of its content (mitochondria, lysosomes, peroxisomes, glycogen, etc.).

The sinusoids between the hepatocyte plates are lined with endothelial cells not easily seen in this section, and with the stellate Kupffer macrophages (arrowhead).

The small bile canaliculi are also difficult to identify in this thick section.

Stain: H–­­E
Magnification: ×1000