At the base of the gastric glands the zymogenic cells (+) are deeply stained with hematoxylin and the parietal cells (P) are well stained with eosin, due to their acidophilic mitochondria.

In one of the well-stained parietal cells, a lightly stained perinuclear intracellular canaliculus (arrow) is clearly visible. This small canaliculus, which opens at the apex of the cell, is the site of the transmembrane flux of ions that leads to the formation of HCl in the lumen of the gland.

Stain: H–­­E
Magnification: ×1100