Finite-element modelling of the human eardrum and middle-ear S. Abou-Khalil McGill University, Montreal, Canada W.R.J. Funnell McGill University, Montreal, Canada Rene G. van Wijhe McGill University, Montreal, Canada W.F.S. Decraemer University of Antwerp (RUCA), Antwerp, Belgium J.J.J. Dirckx University of Antwerp (RUCA), Antwerp, Belgium A number of groups have recently presented finite-element models of the human middle ear. In this work we present such a model which takes advantage of our phase-shift moiré shape measurements to precisely define the shape of the eardrum, as in our previous modelling of the eardrum and middle ear of the cat (ARO 1996) and gerbil (ARO 1999). The moiré measurements are made in the presence of varying static pressures, which both provides a clear definition of the boundaries of the eardrum, and provides displacement measurements with which the model behaviour can be compared. The middle-ear geometry is derived from histological serial sections and from magnetic-resonance microscopy (MRM) data of the human ear. The MRM data sets, having resolutions of tens of microns, are obtained from UNC and The Center for In Vivo Microscopy(CIVM), Duke University. We present simulation results from the model, including comparisons with experimental measurements and simulations of clinical pathological conditions such as ossicular erosion. Supported by Medical Research Council (Canada), Natural Sciences and Engineering Research Council (Canada), and the University of Antwerp. We thank Drs. M.M. and O.W. Henson (UNC) and the CIVM for providing the MRM data, and Dr. S.M. Khanna (Columbia University) for providing the histological material.